Sclerostin Is an Osteocyte-expressed Negative Regulator of Bone Formation, But Not a Classical BMP Antagonist

Sclerosteosis, a skeletal disorder characterized by high bone mass due to increased osteoblast activity, is caused by loss of the SOST gene product, sclerostin. The localization in bone and the mechanism of action of sclerostin are not yet known, but it has been hypothesized that it may act as a bon...

Descripción completa

Detalles Bibliográficos
Autores principales: van Bezooijen, Rutger L., Roelen, Bernard A.J., Visser, Annemieke, van der Wee-Pals, Lianne, de Wilt, Edwin, Karperien, Marcel, Hamersma, Herman, Papapoulos, Socrates E., ten Dijke, Peter, Löwik, Clemens W.G.M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212719/
https://www.ncbi.nlm.nih.gov/pubmed/15024046
http://dx.doi.org/10.1084/jem.20031454

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212719/
https://www.ncbi.nlm.nih.gov/pubmed/15024046
http://dx.doi.org/10.1084/jem.20031454

Ejemplares similares