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Pax5 Activates Immunoglobulin Heavy Chain V to DJ Rearrangement in Transgenic Thymocytes
Mice deficient for the B cell–restricted transcription factor Pax5 show a defect in the V(H) to DJ(H) rearrangement step of immunoglobulin heavy chain gene assembly even though the expression of the V(D)J recombinase is not diminished in Pax5 (−/−) pro–B cells. To investigate whether Pax5 is limitin...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2004
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212727/ https://www.ncbi.nlm.nih.gov/pubmed/15007090 http://dx.doi.org/10.1084/jem.20032249 |