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Ro/SSA autoantibodies directly bind cardiomyocytes, disturb calcium homeostasis, and mediate congenital heart block
Congenital heart block develops in fetuses after placental transfer of Ro/SSA autoantibodies from rheumatic mothers. The condition is often fatal and the majority of live-born children require a pacemaker at an early age. The specific antibody that induces the heart block and the mechanism by which...
Autores principales: | Salomonsson, Stina, Sonesson, Sven-Erik, Ottosson, Lars, Muhallab, Saad, Olsson, Tomas, Sunnerhagen, Maria, Kuchroo, Vijay K., Thorén, Peter, Herlenius, Eric, Wahren-Herlenius, Marie |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2005
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212767/ https://www.ncbi.nlm.nih.gov/pubmed/15630133 http://dx.doi.org/10.1084/jem.20041859 |
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