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The Pim kinases control rapamycin-resistant T cell survival and activation
Although Pim-1 or Pim-2 can contribute to lymphoid transformation when overexpressed, the physiologic role of these kinases in the immune response is uncertain. We now report that T cells from Pim-1(−/−)Pim-2(−/−) animals display an unexpected sensitivity to the immunosuppressant rapamycin. Cytokine...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2005
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212793/ https://www.ncbi.nlm.nih.gov/pubmed/15642745 http://dx.doi.org/10.1084/jem.20042020 |