Cargando…

SOCS1 Is a Suppressor of Liver Fibrosis and Hepatitis-induced Carcinogenesis

Hepatocellular carcinomas (HCCs) mainly develop from liver cirrhosis and severe liver fibrosis that are established with long-lasting inflammation of the liver. Silencing of the suppressor of the cytokine signaling-1 (SOCS1) gene, a negative regulator of cytokine signaling, by DNA methylation has be...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yoshida, Takafumi, Ogata, Hisanobu, Kamio, Masaki, Joo, Akiko, Shiraishi, Hiroshi, Tokunaga, Yoko, Sata, Michio, Nagai, Hisaki, Yoshimura, Akihiko
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2004
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212816/ https://www.ncbi.nlm.nih.gov/pubmed/15197228 http://dx.doi.org/10.1084/jem.20031675

Ejemplares similares

Cis3/Socs3/Ssi3 Plays a Negative Regulatory Role in Stat3 Activation and Intestinal Inflammation
por: Suzuki, Asuka, et al.
Publicado: (2001)

SOCS, inflammation, and cancer
por: Inagaki-Ohara, Kyoko, et al.
Publicado: (2013)

SOCS, Inflammation, and Autoimmunity
por: Yoshimura, Akihiko, et al.
Publicado: (2012)

Activation of STAT3 by the Hepatitis C Virus Core Protein Leads to Cellular Transformation
por: Yoshida, Takafumi, et al.
Publicado: (2002)

SOCS1 and Regulation of Regulatory T Cells Plasticity
por: Takahashi, Reiko, et al.
Publicado: (2014)

Negative regulation of cytokine signaling and immune responses by SOCS proteins
por: Yoshimura, Akihiko, et al.
Publicado: (2005)

A Role of Suppressor of Cytokine Signaling 3 (SOCS3/CIS3/SSI3) in CD28-mediated Interleukin 2 Production
por: Matsumoto, Akira, et al.
Publicado: (2003)

Hepatic stellate cell-intrinsic role of SOCS1 in controlling hepatic fibrogenic response and the pro-inflammatory macrophage compartment during liver fibrosis
por: Kandhi, Rajani, et al.
Publicado: (2023)

Prognostic significance of SOCS1 and SOCS3 tumor suppressors and oncogenic signaling pathway genes in hepatocellular carcinoma
por: Khan, Md Gulam Musawwir, et al.
Publicado: (2020)

Molecular Cloning and Expression Analysis of Three Suppressors of Cytokine Signaling Genes (SOCS5, SOCS6, SOCS7) in the Mealworm Beetle Tenebrio molitor
por: Patnaik, Bharat Bhusan, et al.
Publicado: (2019)

Suppressor of cytokine signaling (SOCS) genes are downregulated in breast cancer
por: Ghafouri-Fard, Soudeh, et al.
Publicado: (2018)

Prostaglandin E2 and SOCS1 have a role in intestinal immune tolerance
por: Chinen, Takatoshi, et al.
Publicado: (2011)

Murine cytomegalovirus infection of mouse macrophages stimulates early expression of suppressor of cytokine signaling (SOCS)1 and SOCS3
por: Alston, Christine I., et al.
Publicado: (2017)

Inhibition of anti-inflammatory pathway through suppressors of cytokine signalling (Socs2/Socs3) in the initiation of hepatocellular carcinoma
por: Ashfaq, Isbah, et al.
Publicado: (2022)

SOCS, SPRED, and NR4a: Negative regulators of cytokine signaling and transcription in immune tolerance
por: YOSHIMURA, Akihiko, et al.
Publicado: (2021)

Insights into the Evolution of the Suppressors of Cytokine Signaling (SOCS) Gene Family in Vertebrates
por: Wang, Bei, et al.
Publicado: (2019)

The Emerging Role of Suppressors of Cytokine Signaling (SOCS) in the Development and Progression of Leukemia
por: Keewan, Esra’a, et al.
Publicado: (2021)

Fish Suppressors of Cytokine Signaling (SOCS): Gene Discovery, Modulation of Expression and Function
por: Wang, Tiehui, et al.
Publicado: (2011)

Tissue levels of suppressor of cytokine signaling-3 (SOCS-3) in mycosis fungoides
por: Nada, Hanan R., et al.
Publicado: (2022)

SOCS1 Deficiency Promotes Hepatocellular Carcinoma via SOCS3-Dependent CDKN1A Induction and NRF2 Activation
por: Khan, Md Gulam Musawwir, et al.
Publicado: (2023)

Roles of STAT3/SOCS3 Pathway in Regulating the Visual Function and Ubiquitin-Proteasome-dependent Degradation of Rhodopsin during Retinal Inflammation
por: Ozawa, Yoko, et al.
Publicado: (2008)

Dysregulation of SOCS-Mediated Negative Feedback of Cytokine Signaling in Carcinogenesis and Its Significance in Cancer Treatment
por: Jiang, Mengmeng, et al.
Publicado: (2017)

Association of Periodontal Diseases and Liver Fibrosis in Patients With HCV and/or HBV infection
por: Nagao, Yumiko, et al.
Publicado: (2014)

Suppressor of cytokine signaling 3 (SOCS3) is not an independent biomarker of colorectal adenoma risk
por: Hamilton, Kathryn E, et al.
Publicado: (2010)

Role of Ubiquitylation in Controlling Suppressor of Cytokine Signalling 3 (SOCS3) Function and Expression
por: Williams, Jamie J. L., et al.
Publicado: (2014)

Regulation of Insulin and Leptin Signaling by Muscle Suppressor of Cytokine Signaling 3 (SOCS3)
por: Yang, Zhenggang, et al.
Publicado: (2012)

Interaction of Abl Tyrosine Kinases with SOCS3 Impairs Its Suppressor Function in Tumorigenesis()()()
por: Feng, Riyue, et al.
Publicado: (2018)

Genetic Basis for Carcinogenesis. Tumor Suppressor Genes and Oncogenes
por: Rabbitts, P.
Publicado: (1992)

Rab25 as a tumour suppressor in colon carcinogenesis
por: Goldenring, J R, et al.
Publicado: (2011)

miR-155-5p Implicates in the Pathogenesis of Renal Fibrosis via Targeting SOCS1 and SOCS6
por: Zhang, Wanfen, et al.
Publicado: (2020)

Elevation of Serum MAGE‐4 Protein Levels and Prediction of Hepatocellular Carcinogenesis in Patients with Liver Cirrhosis
por: Yutani, Shigeru, et al.
Publicado: (2002)

Effects of valproic acid on SOCS-1, SOCS-2, SOCS-3, SOCS-5, SOCS6, and SOCS-7 gene expression and cell growth inhibition in colon carcinoma
por: Sanaei, Masumeh, et al.
Publicado: (2022)

STAT3 deficiency prevents hepatocarcinogenesis and promotes biliary proliferation in thioacetamide-induced liver injury
por: Abe, Mitsuhiko, et al.
Publicado: (2017)

Aberrant methylation of suppressor of cytokine signalling-1 (SOCS-1) gene in pancreatic ductal neoplasms
por: Fukushima, N, et al.
Publicado: (2003)

Two Drosophila suppressors of cytokine signaling (SOCS) differentially regulate JAK and EGFR pathway activities
por: Rawlings, Jason S, et al.
Publicado: (2004)

Suppressor of cytokine signaling (SOCS)-3 gene transfer protects against collagen-induced arthritis
por: van de Loo, FAJ, et al.
Publicado: (2004)

Suppressor of cytokine signalling protein SOCS3 expression is increased at sites of acute and chronic inflammation
por: White, Gemma E., et al.
Publicado: (2011)

Transcriptional down-regulation of suppressor of cytokine signaling (SOCS)-3 in chronic obstructive pulmonary disease
por: Springer, Jochen, et al.
Publicado: (2013)

The suppressor of cytokine signalling 2 (SOCS2), traumatic brain injury and microglial/macrophage regulation
por: Basrai, Harleen S., et al.
Publicado: (2016)

Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling
por: Kedzierski, Lukasz, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_t2d8u9lohj0r339t2klemlje5s