Defined αβ T Cell Receptors with Distinct Ligand Specificities Do Not Require Those Ligands to Signal Double Negative Thymocyte Differentiation

During T cell development in the thymus, pre–T cell receptor (TCR) complexes signal CD4(−) CD8(−) (double negative [DN]) thymocytes to differentiate into CD4(+) CD8(+) (double positive [DP]) thymocytes, and they generate such signals without apparent ligand engagements. Although ligand-independent s...

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Detalles Bibliográficos
Autores principales: Erman, Batu, Guinter, Terry I., Singer, Alfred
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212817/
https://www.ncbi.nlm.nih.gov/pubmed/15210747
http://dx.doi.org/10.1084/jem.20032204

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212817/
https://www.ncbi.nlm.nih.gov/pubmed/15210747
http://dx.doi.org/10.1084/jem.20032204

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