Homeostatic maintenance of natural Foxp3 (+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

Interleukin (IL)-2 plays a crucial role in the maintenance of natural immunologic self-tolerance. Neutralization of circulating IL-2 by anti–IL-2 monoclonal antibody for a limited period elicits autoimmune gastritis in BALB/c mice. Similar treatment of diabetes-prone nonobese diabetic mice triggers...

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Detalles Bibliográficos
Autores principales: Setoguchi, Ruka, Hori, Shohei, Takahashi, Takeshi, Sakaguchi, Shimon
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212841/
https://www.ncbi.nlm.nih.gov/pubmed/15753206
http://dx.doi.org/10.1084/jem.20041982

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212841/
https://www.ncbi.nlm.nih.gov/pubmed/15753206
http://dx.doi.org/10.1084/jem.20041982

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