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Regulation of TCR δ and α repertoires by local and long-distance control of variable gene segment chromatin structure
Murine Tcrd and Tcra gene segments reside in a single genetic locus and undergo recombination in CD4(−)CD8(−) (double negative [DN]) and CD4(+)CD8(+) (double positive [DP]) thymocytes, respectively. TcraTcrd locus variable gene segments are subject to complex regulation. Only a small subset of ∼100...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2005
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212846/ https://www.ncbi.nlm.nih.gov/pubmed/16087716 http://dx.doi.org/10.1084/jem.20050680 |