Inducible DNA breaks in Ig S regions are dependent on AID and UNG

Class switch recombination (CSR) occurs by an intrachromosomal deletion whereby the IgM constant region gene (Cμ) is replaced by a downstream constant region gene. This unique recombination event involves formation of double-strand breaks (DSBs) in immunoglobulin switch (S) regions, and requires act...

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Detalles Bibliográficos
Autores principales: Schrader, Carol E., Linehan, Erin K., Mochegova, Sofia N., Woodland, Robert T., Stavnezer, Janet
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212854/
https://www.ncbi.nlm.nih.gov/pubmed/16103411
http://dx.doi.org/10.1084/jem.20050872

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212854/
https://www.ncbi.nlm.nih.gov/pubmed/16103411
http://dx.doi.org/10.1084/jem.20050872

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