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Inducible DNA breaks in Ig S regions are dependent on AID and UNG

Class switch recombination (CSR) occurs by an intrachromosomal deletion whereby the IgM constant region gene (Cμ) is replaced by a downstream constant region gene. This unique recombination event involves formation of double-strand breaks (DSBs) in immunoglobulin switch (S) regions, and requires act...

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Detalles Bibliográficos
Autores principales:	Schrader, Carol E., Linehan, Erin K., Mochegova, Sofia N., Woodland, Robert T., Stavnezer, Janet
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2005
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212854/ https://www.ncbi.nlm.nih.gov/pubmed/16103411 http://dx.doi.org/10.1084/jem.20050872

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