The timing of TCRα expression critically influences T cell development and selection

Sequential rearrangement of the T cell receptor for antigen (TCR) β and α chains is a hallmark of thymocyte development. This temporal control is lost in TCR transgenics because the α chain is expressed prematurely at the CD4(−)CD8(−) double negative (DN) stage. To test the importance of this, we ex...

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Detalles Bibliográficos
Autores principales: Baldwin, Troy A., Sandau, Michelle M., Jameson, Stephen C., Hogquist, Kristin A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212895/
https://www.ncbi.nlm.nih.gov/pubmed/15998791
http://dx.doi.org/10.1084/jem.20050359

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212895/
https://www.ncbi.nlm.nih.gov/pubmed/15998791
http://dx.doi.org/10.1084/jem.20050359

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