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The timing of TCRα expression critically influences T cell development and selection

Sequential rearrangement of the T cell receptor for antigen (TCR) β and α chains is a hallmark of thymocyte development. This temporal control is lost in TCR transgenics because the α chain is expressed prematurely at the CD4(−)CD8(−) double negative (DN) stage. To test the importance of this, we ex...

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Detalles Bibliográficos
Autores principales:	Baldwin, Troy A., Sandau, Michelle M., Jameson, Stephen C., Hogquist, Kristin A.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2005
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212895/ https://www.ncbi.nlm.nih.gov/pubmed/15998791 http://dx.doi.org/10.1084/jem.20050359

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