Restricted MHC–peptide repertoire predisposes to autoimmunity

MHC molecules associated with autoimmunity possess known structural features that limit the repertoire of peptides that they can present. Such limitation gives a selective advantage to TCRs that rely on interaction with the MHC itself, rather than with the peptide residues. At the same time, negativ...

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Detalles Bibliográficos
Autores principales: Logunova, Nadezda N., Viret, Christophe, Pobezinsky, Leonid A., Miller, Sara A., Kazansky, Dmitri B., Sundberg, John P., Chervonsky, Alexander V.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212910/
https://www.ncbi.nlm.nih.gov/pubmed/15998789
http://dx.doi.org/10.1084/jem.20050198

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212910/
https://www.ncbi.nlm.nih.gov/pubmed/15998789
http://dx.doi.org/10.1084/jem.20050198

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