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Modifier loci condition autoimmunity provoked by Aire deficiency
Loss of function mutations in the autoimmune regulator (Aire) gene in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy patients and mutant mice lead to autoimmune manifestations that segregate as a monogenic trait, but with wide variation in the spectrum of organs targeted. To investig...
Autores principales: | Jiang, Wenyu, Anderson, Mark S., Bronson, Roderick, Mathis, Diane, Benoist, Christophe |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2005
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212943/ https://www.ncbi.nlm.nih.gov/pubmed/16172259 http://dx.doi.org/10.1084/jem.20050693 |
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