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BAFF regulates B cell survival by downregulating the BH3-only family member Bim via the ERK pathway

The B cell activating factor belonging to the tumor necrosis factor family (BAFF) is required for B cell survival and maturation. The mechanisms by which BAFF mediates B cell survival are less understood. We found that BAFF and a proliferation-inducing ligand (APRIL), which are related, block B cell...

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Detalles Bibliográficos
Autores principales: Craxton, Andrew, Draves, Kevin E., Gruppi, Adriana, Clark, Edward A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212971/
https://www.ncbi.nlm.nih.gov/pubmed/16301744
http://dx.doi.org/10.1084/jem.20051283