Toll-like receptor–independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation

Deoxyribonuclease (DNase) II in macrophages cleaves the DNA of engulfed apoptotic cells and of nuclei expelled from erythroid precursor cells. DNase II–deficient mouse embryos accumulate undigested DNA in macrophages, and die in feto because of the activation of the interferon β (IFN β) gene. Here,...

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Detalles Bibliográficos
Autores principales: Okabe, Yasutaka, Kawane, Kohki, Akira, Shizuo, Taniguchi, Tadatsugu, Nagata, Shigekazu
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212973/
https://www.ncbi.nlm.nih.gov/pubmed/16301743
http://dx.doi.org/10.1084/jem.20051654

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212973/
https://www.ncbi.nlm.nih.gov/pubmed/16301743
http://dx.doi.org/10.1084/jem.20051654

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