Cargando…
Toll-like receptor–independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation
Deoxyribonuclease (DNase) II in macrophages cleaves the DNA of engulfed apoptotic cells and of nuclei expelled from erythroid precursor cells. DNase II–deficient mouse embryos accumulate undigested DNA in macrophages, and die in feto because of the activation of the interferon β (IFN β) gene. Here,...
Autores principales: | Okabe, Yasutaka, Kawane, Kohki, Akira, Shizuo, Taniguchi, Tadatsugu, Nagata, Shigekazu |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2005
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212973/ https://www.ncbi.nlm.nih.gov/pubmed/16301743 http://dx.doi.org/10.1084/jem.20051654 |
Ejemplares similares
-
DNA degradation during apoptotic cell death
por: Nagata, S
Publicado: (2003) -
Regulation of mammalian horizontal gene transfer by apoptotic DNA fragmentation
por: Yan, B, et al.
Publicado: (2006) -
Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus
por: Christensen, Sean R., et al.
Publicado: (2005) -
Mitochondrial DNA That Escapes from Autophagy Causes Inflammation and Heart Failure
por: Oka, Takafumi, et al.
Publicado: (2012) -
Collaborative Induction of Inflammatory Responses by Dectin-1 and Toll-like Receptor 2
por: Gantner, Benjamin N., et al.
Publicado: (2003)