MSH2–MSH6 stimulates DNA polymerase η, suggesting a role for A:T mutations in antibody genes

Activation-induced cytidine deaminase deaminates cytosine to uracil (dU) in DNA, which leads to mutations at C:G basepairs in immunoglobulin genes during somatic hypermutation. The mechanism that generates mutations at A:T basepairs, however, remains unclear. It appears to require the MSH2–MSH6 mism...

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Detalles Bibliográficos
Autores principales: Wilson, Teresa M., Vaisman, Alexandra, Martomo, Stella A., Sullivan, Patsa, Lan, Li, Hanaoka, Fumio, Yasui, Akira, Woodgate, Roger, Gearhart, Patricia J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213055/
https://www.ncbi.nlm.nih.gov/pubmed/15710654
http://dx.doi.org/10.1084/jem.20042066

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213055/
https://www.ncbi.nlm.nih.gov/pubmed/15710654
http://dx.doi.org/10.1084/jem.20042066

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