Cargando…
MSH2–MSH6 stimulates DNA polymerase η, suggesting a role for A:T mutations in antibody genes
Activation-induced cytidine deaminase deaminates cytosine to uracil (dU) in DNA, which leads to mutations at C:G basepairs in immunoglobulin genes during somatic hypermutation. The mechanism that generates mutations at A:T basepairs, however, remains unclear. It appears to require the MSH2–MSH6 mism...
| Autores principales: | , , , , , , , , |
|---|---|
| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2005
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213055/ https://www.ncbi.nlm.nih.gov/pubmed/15710654 http://dx.doi.org/10.1084/jem.20042066 |