Calcium-sensing soluble adenylyl cyclase mediates TNF signal transduction in human neutrophils

Through chemical screening, we identified a pyrazolone that reversibly blocked the activation of phagocyte oxidase (phox) in human neutrophils in response to tumor necrosis factor (TNF) or formylated peptide. The pyrazolone spared activation of phox by phorbol ester or bacteria, bacterial killing, T...

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Detalles Bibliográficos
Autores principales: Han, Hyunsil, Stessin, Alexander, Roberts, Julia, Hess, Kenneth, Gautam, Narinder, Kamenetsky, Margarita, Lou, Olivia, Hyde, Edward, Nathan, Noah, Muller, William A., Buck, Jochen, Levin, Lonny R., Nathan, Carl
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213086/
https://www.ncbi.nlm.nih.gov/pubmed/16043520
http://dx.doi.org/10.1084/jem.20050778

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213086/
https://www.ncbi.nlm.nih.gov/pubmed/16043520
http://dx.doi.org/10.1084/jem.20050778

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