Balancing diversity and tolerance: lessons from patients with systemic lupus erythematosus

The autoimmune disease systemic lupus erythematosus (SLE) is caused by a failure of B cell tolerance. Recent studies in mouse models of SLE have identified several distinct tolerance checkpoints that must each function appropriately to protect against disease. However, studies of B cell repertoire s...

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Detalles Bibliográficos
Autores principales: Jacobi, Annett M., Diamond, Betty
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213089/
https://www.ncbi.nlm.nih.gov/pubmed/16061723
http://dx.doi.org/10.1084/jem.20050221
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author Jacobi, Annett M.
Diamond, Betty
author_facet Jacobi, Annett M.
Diamond, Betty
author_sort Jacobi, Annett M.
collection PubMed
description The autoimmune disease systemic lupus erythematosus (SLE) is caused by a failure of B cell tolerance. Recent studies in mouse models of SLE have identified several distinct tolerance checkpoints that must each function appropriately to protect against disease. However, studies of B cell repertoire selection in humans are essential to understand which checkpoints are defective in human autoimmune diseases.
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spelling pubmed-22130892008-03-11 Balancing diversity and tolerance: lessons from patients with systemic lupus erythematosus Jacobi, Annett M. Diamond, Betty J Exp Med Commentary The autoimmune disease systemic lupus erythematosus (SLE) is caused by a failure of B cell tolerance. Recent studies in mouse models of SLE have identified several distinct tolerance checkpoints that must each function appropriately to protect against disease. However, studies of B cell repertoire selection in humans are essential to understand which checkpoints are defective in human autoimmune diseases. The Rockefeller University Press 2005-08-01 /pmc/articles/PMC2213089/ /pubmed/16061723 http://dx.doi.org/10.1084/jem.20050221 Text en Copyright © 2005, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Jacobi, Annett M.
Diamond, Betty
Balancing diversity and tolerance: lessons from patients with systemic lupus erythematosus
title Balancing diversity and tolerance: lessons from patients with systemic lupus erythematosus
title_full Balancing diversity and tolerance: lessons from patients with systemic lupus erythematosus
title_fullStr Balancing diversity and tolerance: lessons from patients with systemic lupus erythematosus
title_full_unstemmed Balancing diversity and tolerance: lessons from patients with systemic lupus erythematosus
title_short Balancing diversity and tolerance: lessons from patients with systemic lupus erythematosus
title_sort balancing diversity and tolerance: lessons from patients with systemic lupus erythematosus
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213089/
https://www.ncbi.nlm.nih.gov/pubmed/16061723
http://dx.doi.org/10.1084/jem.20050221
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