A mutation in the Icsbp1 gene causes susceptibility to infection and a chronic myeloid leukemia–like syndrome in BXH-2 mice

BXH-2 mice develop a fatal myeloid leukemia by a two-step mutagenic process. First, a BXH-2–specific recessive mutation causes a myeloproliferative syndrome. Second, retroviral insertions alter oncogenes or tumor suppressors, resulting in clonal expansion of leukemic cells. We have identified a rece...

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Detalles Bibliográficos
Autores principales: Turcotte, Karine, Gauthier, Susan, Tuite, Ashleigh, Mullick, Alaka, Malo, Danielle, Gros, Philippe
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213093/
https://www.ncbi.nlm.nih.gov/pubmed/15781580
http://dx.doi.org/10.1084/jem.20042170

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213093/
https://www.ncbi.nlm.nih.gov/pubmed/15781580
http://dx.doi.org/10.1084/jem.20042170

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