Cargando…

Repeated stimulation of CD4 effector T cells can limit their protective function

Chronic infections often result in CD8 T-cell deletion or functional nonresponsiveness. However, to date no definitive studies have attempted to determine the impact of repeated T cell receptor stimulation on CD4 effector T cell generation. We have determined that when antigen presentation is limite...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jelley-Gibbs, Dawn M., Dibble, John P., Filipson, Svetlana, Haynes, Laura, Kemp, Roslyn A., Swain, Susan L.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2005
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213138/ https://www.ncbi.nlm.nih.gov/pubmed/15795235 http://dx.doi.org/10.1084/jem.20041852

Ejemplares similares

Unexpected prolonged presentation of influenza antigens promotes CD4 T cell memory generation
por: Jelley-Gibbs, Dawn M., et al.
Publicado: (2005)

Mitochondrial Ca(2+) and membrane potential, an alternative pathway for Interleukin 6 to regulate CD4 cell effector function
por: Yang, Rui, et al.
Publicado: (2015)

Interleukin 2, but Not Other Common γ Chain–Binding Cytokines, Can Reverse the Defect in Generation of Cd4 Effector T Cells from Naive T Cells of Aged Mice
por: Haynes, Laura, et al.
Publicado: (1999)

CD134/CD137 Dual Costimulation-Elicited IFN-γ Maximizes Effector T Cell Function but Limits Treg Expansion
por: Rose, Marie-Clare St., et al.
Publicado: (2013)

The route of priming influences the ability of respiratory virus–specific memory CD8(+) T cells to be activated by residual antigen
por: Takamura, Shiki, et al.
Publicado: (2010)

IL-7 Promotes the Transition of CD4 Effectors to Persistent Memory Cells
por: Li, JiChu, et al.
Publicado: (2003)

Pathogen Recognition by CD4 Effectors Drives Key Effector and Most Memory Cell Generation Against Respiratory Virus
por: Devarajan, Priyadharshini, et al.
Publicado: (2018)

Rapid default transition of CD4 T cell effectors to functional memory cells
por: McKinstry, K. Kai, et al.
Publicado: (2007)

CD4 Effector T Cell Subsets in the Response to Influenza: Heterogeneity, Migration, and Function
por: Román, Eulogia, et al.
Publicado: (2002)

B7-H1 limits the entry of effector CD8(+) T cells to the memory pool by upregulating Bim
por: Gibbons, Rachel M., et al.
Publicado: (2012)

Cognate Antigen Stimulation Generates Potent CD8(+) Inflammatory Effector T Cells
por: Sung, Hsueh-Cheng, et al.
Publicado: (2013)

Protection by and maintenance of CD4 effector memory and effector T cell subsets in persistent malaria infection
por: Opata, Michael M., et al.
Publicado: (2018)

Memory CD8(+) T cells upregulate glycolysis and effector functions under limiting oxygen conditions
por: Beumer‐Chuwonpad, Ammarina, et al.
Publicado: (2022)

Interferon γ Eliminates Responding Cd4 T Cells during Mycobacterial Infection by Inducing Apoptosis of Activated Cd4 T Cells
por: Dalton, Dyana K., et al.
Publicado: (2000)

Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection
por: Khader, Shabaana A., et al.
Publicado: (2006)

Transient expression of ZBTB32 in anti-viral CD8(+) T cells limits the magnitude of the effector response and the generation of memory
por: Shin, Hyun Mu, et al.
Publicado: (2017)

Repeat-containing protein effectors of plant-associated organisms
por: Mesarich, Carl H., et al.
Publicado: (2015)

Effector CD4 T cell transition to memory requires late cognate interactions that induce autocrine IL-2
por: McKinstry, K. Kai, et al.
Publicado: (2014)

Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells
por: O'Leary, Claire E., et al.
Publicado: (2016)

Protective Effector Memory CD4 T Cells Depend on ICOS for Survival
por: Moore, Tamson V., et al.
Publicado: (2011)

The Biological Outcome of CD40 Signaling Is Dependent on the Duration of CD40 Ligand Expression: Reciprocal Regulation by Interleukin (IL)-4 and IL-12
por: Lee, Byung O., et al.
Publicado: (2002)

T cell receptor signaling strength establishes the chemotactic properties of effector CD8(+) T cells that control tissue-residency
por: Abdelbary, Mahmoud, et al.
Publicado: (2023)

Complement receptor CD46 co-stimulates optimal human CD8(+) T cell effector function via fatty acid metabolism
por: Arbore, Giuseppina, et al.
Publicado: (2018)

Increased Cell Surface Free Thiols Identify Effector CD8(+) T Cells Undergoing T Cell Receptor Stimulation
por: Pellom, Samuel Troy, et al.
Publicado: (2013)

Interferon-stimulated genes and their antiviral effector functions
por: Schoggins, John W, et al.
Publicado: (2011)

Heterogeneity of human effector CD4(+ )T cells
por: Annunziato, Francesco, et al.
Publicado: (2009)

Ehrlichia chaffeensis Tandem Repeat Effector Targets Differentially Influence Infection
por: Luo, Tian, et al.
Publicado: (2017)

The effect of increasing numbers of repeats on TAL effector DNA binding specificity
por: Rinaldi, Fabio C., et al.
Publicado: (2017)

Expanded antigen-experienced CD160(+)CD8(+)effector T cells exhibit impaired effector functions in chronic lymphocytic leukemia
por: Bozorgmehr, Najmeh, et al.
Publicado: (2021)

CD40-Activated B Cells Can Efficiently Prime Antigen-Specific Naïve CD8(+) T Cells to Generate Effector but Not Memory T cells
por: Mathieu, Mélissa, et al.
Publicado: (2012)

Effector CD4 and CD8 T Cells and Their Role in the Tumor Microenvironment
por: Hadrup, Sine, et al.
Publicado: (2012)

Regulation of CD4(+) and CD8(+) Effector Responses by Sprouty-1
por: Collins, Sam, et al.
Publicado: (2012)

“Can you see my screen?” Addressing Racial and Ethnic Disparities in Telehealth
por: Haynes, Norrisa, et al.
Publicado: (2021)

Disruption of IL-33 Signaling Limits Early CD8+ T Cell Effector Function Leading to Exhaustion in Murine Hemophagocytic Lymphohistiocytosis
por: Rood, Julia E., et al.
Publicado: (2018)

Temporal Dynamics of CD8(+) T Cell Effector Responses during Primary HIV Infection
por: Demers, Korey R., et al.
Publicado: (2016)

CD4(+) T effector memory cell responses in Chlamydia pneumoniae‐stimulated peripheral blood mononuclear cells in nonasthmatic subjects
por: Smith‐Norowitz, Tamar A., et al.
Publicado: (2022)

Strong influenza-induced T(FH) generation requires CD4 effectors to recognize antigen locally and receive signals from continuing infection
por: Devarajan, Priyadharshini, et al.
Publicado: (2022)

Butyrate limits human natural killer cell effector function
por: Zaiatz-Bittencourt, Vanessa, et al.
Publicado: (2023)

Central and Effector Memory Human CD4(+) and CD8(+) T Cells during Cutaneous Leishmaniasis and after In Vitro Stimulation with Leishmania (Viannia) braziliensis Epitopes
por: de Oliveira, Beatriz Coutinho, et al.
Publicado: (2023)

Effector CD4 T cells with progenitor potential mediate chronic intestinal inflammation
por: Shin, Boyoung, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_n98j5m3f3jomf27dsql7a5u2hf