An anti-CD45RO/RB monoclonal antibody modulates T cell responses via induction of apoptosis and generation of regulatory T cells

The effects of a chimeric monoclonal antibody (chA6 mAb) that recognizes both the RO and RB isoforms of the transmembrane protein tyrosine phosphatase CD45 on human T cells were investigated. Chimeric A6 (chA6) mAb potently inhibited antigen-specific and polyclonal T cell responses. ChA6 mAb induced...

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Detalles Bibliográficos
Autores principales: Gregori, Silvia, Mangia, Patrizia, Bacchetta, Rosa, Tresoldi, Eleonora, Kolbinger, Frank, Traversari, Catia, Carballido, Josè M., de Vries, Jan E., Korthäuer, Ulf, Roncarolo, Maria-Grazia
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213149/
https://www.ncbi.nlm.nih.gov/pubmed/15837814
http://dx.doi.org/10.1084/jem.20040912

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213149/
https://www.ncbi.nlm.nih.gov/pubmed/15837814
http://dx.doi.org/10.1084/jem.20040912

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