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Conditional deletion reveals a cell-autonomous requirement of SLP-76 for thymocyte selection
The SH2 domain containing leukocyte phosphoprotein of 76 kD (SLP-76) is critical for pre-TCR–mediated maturation to the CD4(+)CD8(+) double positive (DP) stage in the thymus. The absolute block in SLP-76(null) mice at the CD4(−)CD8(−)CD44(−)CD25(+) (double-negative 3, DN3) stage has hindered our und...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2005
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213170/ https://www.ncbi.nlm.nih.gov/pubmed/16186188 http://dx.doi.org/10.1084/jem.20051128 |