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Density of the Notch ligand Delta1 determines generation of B and T cell precursors from hematopoietic stem cells
Notch signaling regulates multiple cell fate decisions by hematopoietic precursors. To address whether different amounts of Notch ligand influence lineage choices, we cultured murine bone marrow lin(−)Sca-1(+)c-kit(+) cells with increasing densities of immobilized Delta1(ext-IgG) consisting of the e...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2005
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213184/ https://www.ncbi.nlm.nih.gov/pubmed/15851488 http://dx.doi.org/10.1084/jem.20042450 |