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Density of the Notch ligand Delta1 determines generation of B and T cell precursors from hematopoietic stem cells

Notch signaling regulates multiple cell fate decisions by hematopoietic precursors. To address whether different amounts of Notch ligand influence lineage choices, we cultured murine bone marrow lin(−)Sca-1(+)c-kit(+) cells with increasing densities of immobilized Delta1(ext-IgG) consisting of the e...

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Detalles Bibliográficos
Autores principales:	Dallas, Mari H., Varnum-Finney, Barbara, Delaney, Colleen, Kato, Keizo, Bernstein, Irwin D.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2005
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213184/ https://www.ncbi.nlm.nih.gov/pubmed/15851488 http://dx.doi.org/10.1084/jem.20042450

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