PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis

Although the transcription factor PU.1 is essential for fetal lymphomyelopoiesis, we unexpectedly found that elimination of the gene in adult mice allowed disturbed hematopoiesis, dominated by granulocyte production. Impaired production of lymphocytes was evident in PU.1-deficient bone marrow (BM),...

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Detalles Bibliográficos
Autores principales: Dakic, Aleksandar, Metcalf, Donald, Di Rago, Ladina, Mifsud, Sandra, Wu, Li, Nutt, Stephen L.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213186/
https://www.ncbi.nlm.nih.gov/pubmed/15867096
http://dx.doi.org/10.1084/jem.20050075

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213186/
https://www.ncbi.nlm.nih.gov/pubmed/15867096
http://dx.doi.org/10.1084/jem.20050075

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