Cargando…
Intricate targeting of immunoglobulin somatic hypermutation maximizes the efficiency of affinity maturation
It is believed that immunoglobulin-variable region gene (IgV) somatic hypermutation (SHM) is initiated by activation-induced cytidine deaminase (AID) upon deamination of cytidine to deoxyuracil. Patch-excision repair of these lesions involving error prone DNA polymerases such as polη causes mutation...
| Autores principales: | , , , |
|---|---|
| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2005
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213188/ https://www.ncbi.nlm.nih.gov/pubmed/15867095 http://dx.doi.org/10.1084/jem.20042483 |