Cargando…

Intricate targeting of immunoglobulin somatic hypermutation maximizes the efficiency of affinity maturation

It is believed that immunoglobulin-variable region gene (IgV) somatic hypermutation (SHM) is initiated by activation-induced cytidine deaminase (AID) upon deamination of cytidine to deoxyuracil. Patch-excision repair of these lesions involving error prone DNA polymerases such as polη causes mutation...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zheng, Nai-Ying, Wilson, Kenneth, Jared, Matthew, Wilson, Patrick C.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2005
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213188/ https://www.ncbi.nlm.nih.gov/pubmed/15867095 http://dx.doi.org/10.1084/jem.20042483

Ejemplares similares

Immunoglobulin somatic hypermutation in a defined biochemical system recapitulates affinity maturation and permits antibody optimization
por: Jeong, Soo Lim, et al.
Publicado: (2022)

Somatic Hypermutation Introduces Insertions and Deletions into Immunoglobulin V Genes
por: Wilson, Patrick C., et al.
Publicado: (1998)

“First AID” for T cell adoptive transfer: TCR affinity maturation by somatic hypermutation
por: Gozlan, Yosi M, et al.
Publicado: (2013)

Somatic hypermutation of an immunoglobulin mu heavy chain transgene
Publicado: (1993)

The Role of DNA Repair in Somatic Hypermutation of Immunoglobulin Genes
por: Kim, Nayun, et al.
Publicado: (1998)

Targeting Of Somatic Hypermutation By immunoglobulin Enhancer And Enhancer-Like Sequences
por: Buerstedde, Jean-Marie, et al.
Publicado: (2014)

Chicken MBD4 Regulates Immunoglobulin Diversification by Somatic Hypermutation
por: Costello, Ryan, et al.
Publicado: (2019)

Control of gene conversion and somatic hypermutation by immunoglobulin promoter and enhancer sequences
por: Yang, Shu Yuan, et al.
Publicado: (2006)

Disparate roles of ATR and ATM in immunoglobulin class switch recombination and somatic hypermutation
por: Pan-Hammarström, Qiang, et al.
Publicado: (2006)

HMCES protects immunoglobulin genes specifically from deletions during somatic hypermutation
por: Wu, Lizhen, et al.
Publicado: (2022)

Tandem Substitutions in Somatic Hypermutation
por: Sepúlveda-Yáñez, Julieta H., et al.
Publicado: (2022)

Altering the spectrum of immunoglobulin V gene somatic hypermutation by modifying the active site of AID
por: Wang, Meng, et al.
Publicado: (2010)

Altered Immunoglobulin Repertoire and Decreased IgA Somatic Hypermutation in the Gut during Chronic HIV-1 Infection
por: Jones, Sean T., et al.
Publicado: (2022)

Identifying protein–protein interactions in somatic hypermutation
por: Goodman, Myron F., et al.
Publicado: (2005)

Continuing rearrangement but absence of somatic hypermutation in immunoglobulin genes of human B cell precursor leukemia
Publicado: (1988)

Attracting AID to targets of somatic hypermutation
por: Tanaka, Atsushi, et al.
Publicado: (2010)

AID function in somatic hypermutation and class switch recombination: AID function in somatic hypermutation and class switch recombination
por: Yu, Kefei
Publicado: (2022)

Activation-induced Deaminase (AID)-directed Hypermutation in the Immunoglobulin Sμ Region: Implication of AID Involvement in a Common Step of Class Switch Recombination and Somatic Hypermutation
por: Nagaoka, Hitoshi, et al.
Publicado: (2002)

Recurrent targets of aberrant somatic hypermutation in lymphoma
por: Khodabakhshi, Alireza Hadj, et al.
Publicado: (2012)

A Role for PCNA Ubiquitination in Immunoglobulin Hypermutation
por: Arakawa, Hiroshi, et al.
Publicado: (2006)

Enhancers Improve the AID-Induced Hypermutation in Episomal Vector for Antibody Affinity Maturation in Mammalian Cell Display
por: Chen, Chuan, et al.
Publicado: (2018)

Models of Somatic Hypermutation Targeting and Substitution Based on Synonymous Mutations from High-Throughput Immunoglobulin Sequencing Data
por: Yaari, Gur, et al.
Publicado: (2013)

Somatic Hypermutations in the V(H) Segment of Immunoglobulin Genes of CDS‐positive Diffuse Large B‐Cell Lymphomas
por: Kume, Masaaki, et al.
Publicado: (1997)

High Affinity Humanized Antibodies without Making Hybridomas; Immunization Paired with Mammalian Cell Display and In Vitro Somatic Hypermutation
por: McConnell, Audrey D., et al.
Publicado: (2012)

UNG shapes the specificity of AID-induced somatic hypermutation
por: Pérez-Durán, Pablo, et al.
Publicado: (2012)

Checkpoint kinase 1 negatively regulates somatic hypermutation
por: Frankenberger, Samantha, et al.
Publicado: (2014)

Ultradeep analysis of tumor heterogeneity in regions of somatic hypermutation
por: Spence, Janice M, et al.
Publicado: (2015)

Restriction of AID activity and somatic hypermutation by PARP-1
por: Tepper, Sandra, et al.
Publicado: (2019)

Topologically Associated Domains Delineate Susceptibility to Somatic Hypermutation
por: Senigl, Filip, et al.
Publicado: (2019)

XRCC1 suppresses somatic hypermutation and promotes alternative nonhomologous end joining in Igh genes
por: Saribasak, Huseyin, et al.
Publicado: (2011)

Msh2 ATPase Activity Is Essential for Somatic Hypermutation at A-T Basepairs and for Efficient Class Switch Recombination
por: Martin, Alberto, et al.
Publicado: (2003)

H2AX Is Required for Recombination Between Immunoglobulin Switch Regions but Not for Intra-Switch Region Recombination or Somatic Hypermutation
por: Reina-San-Martin, Bernardo, et al.
Publicado: (2003)

Somatic hypermutation of immunoglobulin genes: lessons from proliferating cell nuclear antigen(K164R) mutant mice
por: Langerak, Petra, et al.
Publicado: (2008)

Integrity of immunoglobulin variable regions is supported by GANP during AID-induced somatic hypermutation in germinal center B cells
por: Eid, Mohammed Mansour Abbas, et al.
Publicado: (2017)

Immunoglobulin somatic hypermutation has clinical impact in DLBCL and potential implications for immune checkpoint blockade and neoantigen-based immunotherapies
por: Xu-Monette, Zijun Y., et al.
Publicado: (2019)

Expression of human AID in yeast induces mutations in context similar to the context of somatic hypermutation at G-C pairs in immunoglobulin genes
por: Mayorov, Vladimir I, et al.
Publicado: (2005)

A Hypermutable Insert in an Immunoglobulin Transgene Contains Hotspots of Somatic Mutation and Sequences Predicting Highly Stable Structures in the RNA Transcript
por: Storb, Ursula, et al.
Publicado: (1998)

P20-20 LB. Indels in V4 share sequence features with insertions and deletions during somatic hypermutation of immunoglobulins
por: Guglietta, S, et al.
Publicado: (2009)

Expression of Constitutive Fusion of Ubiquitin to PCNA Restores the Level of Immunoglobulin A/T Mutations During Somatic Hypermutation in the Ramos Cell Line
por: Lerner, Leticia K., et al.
Publicado: (2022)

A Bayesian model based computational analysis of the relationship between bisulfite accessible single-stranded DNA in chromatin and somatic hypermutation of immunoglobulin genes
por: Yu, Guojun, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_bb4msif5lvth3b9ulu8cg0tf6v