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Intricate targeting of immunoglobulin somatic hypermutation maximizes the efficiency of affinity maturation

It is believed that immunoglobulin-variable region gene (IgV) somatic hypermutation (SHM) is initiated by activation-induced cytidine deaminase (AID) upon deamination of cytidine to deoxyuracil. Patch-excision repair of these lesions involving error prone DNA polymerases such as polη causes mutation...

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Detalles Bibliográficos
Autores principales:	Zheng, Nai-Ying, Wilson, Kenneth, Jared, Matthew, Wilson, Patrick C.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2005
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213188/ https://www.ncbi.nlm.nih.gov/pubmed/15867095 http://dx.doi.org/10.1084/jem.20042483

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