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The 3′ end of the heavy chain constant region locus enhances germline transcription and switch recombination of the four γ genes

The switch in immunoglobulin (Ig) heavy chain class is preceded by germline transcription and then mediated by a DNA recombination event. To study germline transcription and class switch recombination we used transgenic mice with a 230-kilobase bacterial artificial chromosome that included a rearran...

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Detalles Bibliográficos
Autores principales: Dunnick, Wesley A., Shi, Jian, Graves, Kevin A., Collins, John T.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213191/
https://www.ncbi.nlm.nih.gov/pubmed/15851486
http://dx.doi.org/10.1084/jem.20041988