The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation

Thousands of potentially antigenic peptides are encoded by an infecting pathogen; however, only a small proportion induce measurable CD8( + ) T cell responses. To investigate the factors that control peptide immunogenicity, we have examined the cytotoxic T lymphocyte (CTL) response to a previously u...

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Detalles Bibliográficos
Autores principales: Tynan, Fleur E., Elhassen, Diah, Purcell, Anthony W., Burrows, Jacqueline M., Borg, Natalie A., Miles, John J., Williamson, Nicholas A., Green, Kate J., Tellam, Judy, Kjer-Nielsen, Lars, McCluskey, James, Rossjohn, Jamie, Burrows, Scott R.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213230/
https://www.ncbi.nlm.nih.gov/pubmed/16275762
http://dx.doi.org/10.1084/jem.20050864

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213230/
https://www.ncbi.nlm.nih.gov/pubmed/16275762
http://dx.doi.org/10.1084/jem.20050864

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