Mutational escape from CD8(+) T cell immunity: HCV evolution, from chimpanzees to man

The mechanisms by which the hepatitis C virus (HCV) establishes persistence are not yet fully understood. Previous chimpanzee and now human studies suggest that mutations within MHC class I–restricted HCV epitopes might contribute to viral escape from cytotoxic T lymphocyte (CTL) responses. However,...

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Detalles Bibliográficos
Autores principales: Bowen, David G., Walker, Christopher M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213256/
https://www.ncbi.nlm.nih.gov/pubmed/15939787
http://dx.doi.org/10.1084/jem.20050808
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author Bowen, David G.
Walker, Christopher M.
author_facet Bowen, David G.
Walker, Christopher M.
author_sort Bowen, David G.
collection PubMed
description The mechanisms by which the hepatitis C virus (HCV) establishes persistence are not yet fully understood. Previous chimpanzee and now human studies suggest that mutations within MHC class I–restricted HCV epitopes might contribute to viral escape from cytotoxic T lymphocyte (CTL) responses. However, there are several outstanding questions regarding the role of escape mutations in viral persistence and their fate in the absence of immune selection pressure.
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spelling pubmed-22132562008-03-11 Mutational escape from CD8(+) T cell immunity: HCV evolution, from chimpanzees to man Bowen, David G. Walker, Christopher M. J Exp Med Commentary The mechanisms by which the hepatitis C virus (HCV) establishes persistence are not yet fully understood. Previous chimpanzee and now human studies suggest that mutations within MHC class I–restricted HCV epitopes might contribute to viral escape from cytotoxic T lymphocyte (CTL) responses. However, there are several outstanding questions regarding the role of escape mutations in viral persistence and their fate in the absence of immune selection pressure. The Rockefeller University Press 2005-06-06 /pmc/articles/PMC2213256/ /pubmed/15939787 http://dx.doi.org/10.1084/jem.20050808 Text en Copyright © 2005, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Bowen, David G.
Walker, Christopher M.
Mutational escape from CD8(+) T cell immunity: HCV evolution, from chimpanzees to man
title Mutational escape from CD8(+) T cell immunity: HCV evolution, from chimpanzees to man
title_full Mutational escape from CD8(+) T cell immunity: HCV evolution, from chimpanzees to man
title_fullStr Mutational escape from CD8(+) T cell immunity: HCV evolution, from chimpanzees to man
title_full_unstemmed Mutational escape from CD8(+) T cell immunity: HCV evolution, from chimpanzees to man
title_short Mutational escape from CD8(+) T cell immunity: HCV evolution, from chimpanzees to man
title_sort mutational escape from cd8(+) t cell immunity: hcv evolution, from chimpanzees to man
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213256/
https://www.ncbi.nlm.nih.gov/pubmed/15939787
http://dx.doi.org/10.1084/jem.20050808
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AT walkerchristopherm mutationalescapefromcd8tcellimmunityhcvevolutionfromchimpanzeestoman

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