The Loss of PTEN Allows TCR αβ Lineage Thymocytes to Bypass IL-7 and Pre-TCR–mediated Signaling

The phosphatase and tensin homologue deleted on chromosome 10 (PTEN) negatively regulates cell survival and proliferation mediated by phosphoinositol 3 kinases. We have explored the role of the phosphoinositol(3,4,5)P3-phosphatase PTEN in T cell development by analyzing mice with a T cell–specific d...

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Detalles Bibliográficos
Autores principales: Hagenbeek, Thijs J., Naspetti, Marianne, Malergue, Fabrice, Garçon, Fabien, Nunès, Jacques A., Cleutjens, Kitty B.J.M., Trapman, Jan, Krimpenfort, Paul, Spits, Hergen
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213281/
https://www.ncbi.nlm.nih.gov/pubmed/15452180
http://dx.doi.org/10.1084/jem.20040495

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213281/
https://www.ncbi.nlm.nih.gov/pubmed/15452180
http://dx.doi.org/10.1084/jem.20040495

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