Cargando…

The Loss of PTEN Allows TCR αβ Lineage Thymocytes to Bypass IL-7 and Pre-TCR–mediated Signaling

The phosphatase and tensin homologue deleted on chromosome 10 (PTEN) negatively regulates cell survival and proliferation mediated by phosphoinositol 3 kinases. We have explored the role of the phosphoinositol(3,4,5)P3-phosphatase PTEN in T cell development by analyzing mice with a T cell–specific d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hagenbeek, Thijs J., Naspetti, Marianne, Malergue, Fabrice, Garçon, Fabien, Nunès, Jacques A., Cleutjens, Kitty B.J.M., Trapman, Jan, Krimpenfort, Paul, Spits, Hergen
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2004
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213281/ https://www.ncbi.nlm.nih.gov/pubmed/15452180 http://dx.doi.org/10.1084/jem.20040495

Ejemplares similares

Human Innate Mycobacterium tuberculosis–Reactive αβTCR(+) Thymocytes
por: Gold, Marielle C, et al.
Publicado: (2008)

Increased TCR signal strength in DN thymocytes promotes development of gut TCRαβ((+))CD8αα((+)) intraepithelial lymphocytes
por: Grandjean, Capucine L., et al.
Publicado: (2017)

The Molecular Signature Underlying the Thymic Migration and Maturation of TCRαβ(+)CD4(+)CD8(-) Thymocytes
por: Teng, Fei, et al.
Publicado: (2011)

Premature Expression of T Cell Receptor (Tcr)αβ Suppresses Tcrγδ Gene Rearrangement but Permits Development of γδ Lineage T Cells
por: Terrence, Kathleen, et al.
Publicado: (2000)

The Programmed Cell Death of an Immature Thymocyte Cell Line Transgenic for an αβ TCR and the c-myc Proto-Oncogene
por: Murdjeva, Marianna, et al.
Publicado: (1995)

Characterization of human αβTCR repertoire and discovery of D-D fusion in TCRβ chains
por: Liu, Peipei, et al.
Publicado: (2014)

Structural and Biophysical Insights into the TCRαβ Complex in Chickens
por: Zhang, Lijie, et al.
Publicado: (2020)

Lymph act, TCR αβ, TCR γδ cells in peripheral blood in children with juvenile idiopathic arthritis
por: Mazur-Zielinska, H
Publicado: (2008)

A set point in the selection of the αβTCR T cell repertoire imposed by pre-TCR signaling strength
por: Bovolenta, Elena R., et al.
Publicado: (2022)

Presenilins regulate αβ T cell development by modulating TCR signaling
por: Laky, Karen, et al.
Publicado: (2007)

Revisiting the Discovery of the αβ TCR Complex and Its Co-Receptors
por: Reinherz, Ellis L.
Publicado: (2014)

Single T Cell Sequencing Demonstrates the Functional Role of αβ TCR Pairing in Cell Lineage and Antigen Specificity
por: Carter, Jason A., et al.
Publicado: (2019)

γδTCR immunoglobulin constant region domain exchange in human αβTCRs improves TCR pairing without altering TCR gene-modified T cell function
por: Tao, Changli, et al.
Publicado: (2017)

Transgenic CD8αβ co-receptor rescues endogenous TCR function in TCR-transgenic virus-specific T cells
por: Bajwa, Gagan, et al.
Publicado: (2020)

Characterization and modulation of anti-αβTCR antibodies and their respective binding sites at the βTCR chain to enrich engineered T cells
por: Kierkels, Guido J.J., et al.
Publicado: (2021)

Fit αβ T-cell receptor suppresses leukemogenesis of Pten-deficient thymocytes
por: Gon, Stéphanie, et al.
Publicado: (2018)

The Distinct Contributions of Murine T Cell Receptor (TCR)γδ(+) and TCRαβ(+) T Cells to Different Stages of Chemically Induced Skin Cancer
por: Girardi, Michael, et al.
Publicado: (2003)

The Eδ enhancer controls the generation of CD4(−)CD8(−) αβTCR-expressing T cells that can give rise to different lineages of αβ T cells
por: Aifantis, Iannis, et al.
Publicado: (2006)

Domains of the TCR beta-chain required for early thymocyte development
Publicado: (1996)

Structural Features of the αβTCR Mechanotransduction Apparatus That Promote pMHC Discrimination
por: Brazin, Kristine N., et al.
Publicado: (2015)

Massively parallel interrogation and mining of natively paired human TCRαβ repertoires
por: Spindler, Matthew J., et al.
Publicado: (2020)

Asymmetric framework motion of TCRαβ controls load-dependent peptide discrimination
por: Chang-Gonzalez, Ana C., et al.
Publicado: (2023)

Distinct Features of Canine Non-conventional CD4(−)CD8α(−) Double-Negative TCRαβ(+) vs. TCRγδ(+) T Cells
por: Rabiger, Friederike V., et al.
Publicado: (2019)

Coronin-1A Links Cytoskeleton Dynamics to TCRαβ-Induced Cell Signaling
por: Mugnier, Bénédicte, et al.
Publicado: (2008)

Early molecular events induced by T cell receptor (TCR) signaling in immature CD4+ CD8+ thymocytes: increased synthesis of TCR-alpha protein is an early response to TCR signaling that compensates for TCR-alpha instability, improves TCR assembly, and parallels other indicators of positive selection
Publicado: (1995)

Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes
por: Finlay, David K., et al.
Publicado: (2009)

Active suppression of intestinal CD4(+)TCRαβ(+) T-lymphocyte maturation during the postnatal period
por: Torow, Natalia, et al.
Publicado: (2015)

Maintenance of the EBV-specific CD8(+) TCRαβ repertoire in immunosuppressed lung transplant recipients
por: Nguyen, Thi HO, et al.
Publicado: (2017)

Non-canonicaly recruited TCRαβCD8αα IELs recognize microbial antigens
por: Wojciech, Lukasz, et al.
Publicado: (2018)

Identification and Regulation of TCRαβ(+)CD8αα(+) Intraepithelial Lymphocytes in Murine Oral Mucosa
por: Wu, Ruiqing, et al.
Publicado: (2020)

TCR repertoire and CDR3 motif analyses depict the role of αβ T cells in Ankylosing spondylitis
por: Zheng, Ming, et al.
Publicado: (2019)

Allogeneic TCRαβ deficient CAR T-cells targeting CD123 in acute myeloid leukemia
por: Sugita, Mayumi, et al.
Publicado: (2022)

Rapid Generation of TCR and CD8αβ Transgenic Virus Specific T Cells for Immunotherapy of Leukemia
por: Bajwa, Gagan, et al.
Publicado: (2022)

A Perspective on the Interplay of Ultraviolet-Radiation, Skin Microbiome and Skin Resident Memory TCRαβ+ Cells
por: Patra, VijayKumar, et al.
Publicado: (2018)

Comprehensive analysis of structural and sequencing data reveals almost unconstrained chain pairing in TCRαβ complex
por: Shcherbinin, Dmitrii S., et al.
Publicado: (2020)

Frequency and functional profile of circulating TCRαβ(+) double negative T cells in HIV/TB co-infection
por: Tan, Yuting, et al.
Publicado: (2022)

Erratum: Rapid generation of TCR and CD8αβ transgenic virus specific T cells for immunotherapy of leukemia
Publicado: (2023)

Pim1 Reconstitutes Thymus Cellularity in Interleukin 7–And Common γ Chain–Mutant Mice and Permits Thymocyte Maturation in Rag- but Not Cd3γ-Deficient Mice
por: Jacobs, Heinz, et al.
Publicado: (1999)

Pre-TCRα and TCRα Are Not Interchangeable Partners of TCRβ during T Lymphocyte Development
por: Borowski, Christine, et al.
Publicado: (2004)

Anaplastic large cell lymphoma arises in thymocytes and requires transient TCR expression for thymic egress
por: Malcolm, Tim I. M., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_3kacb0l9b8f99kr5gvuosk0l5h