GATA-2 Plays Two Functionally Distinct Roles during the Ontogeny of Hematopoietic Stem Cells

GATA-2 is an essential transcription factor in the hematopoietic system that is expressed in hematopoietic stem cells (HSCs) and progenitors. Complete deficiency of GATA-2 in the mouse leads to severe anemia and embryonic lethality. The role of GATA-2 and dosage effects of this transcription factor...

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Detalles Bibliográficos
Autores principales: Ling, Kam-Wing, Ottersbach, Katrin, van Hamburg, Jan Piet, Oziemlak, Aneta, Tsai, Fong-Ying, Orkin, Stuart H., Ploemacher, Rob, Hendriks, Rudi W., Dzierzak, Elaine
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213282/
https://www.ncbi.nlm.nih.gov/pubmed/15466621
http://dx.doi.org/10.1084/jem.20031556

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213282/
https://www.ncbi.nlm.nih.gov/pubmed/15466621
http://dx.doi.org/10.1084/jem.20031556

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