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Mapping of a Functional Recombination Motif that Defines Isotype Specificity for μ→γ3 Switch Recombination Implicates NF-κB p50 as the Isotype-specific Switching Factor

Ig class switch recombination (CSR) requires expression of activation-induced deaminase (AID) and production of germline transcripts to target S regions for recombination. However, the mechanism of CSR remains unclear. Here we show that an extrachromosomal S plasmid assay is AID dependent and that a...

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Detalles Bibliográficos
Autores principales: Kenter, Amy L., Wuerffel, Robert, Dominguez, Carmen, Shanmugam, Ananth, Zhang, Hongmei
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213297/
https://www.ncbi.nlm.nih.gov/pubmed/14993249
http://dx.doi.org/10.1084/jem.20031935