Inactivation of c-Cbl Reverses Neonatal Lethality and T Cell Developmental Arrest of SLP-76–deficient Mice

c-Cbl is an adaptor protein that negatively regulates signal transduction events involved in thymic-positive selection. To further characterize the function of c-Cbl in T cell development, we analyzed the effect of c-Cbl inactivation in mice deficient in the scaffolding molecule SLP-76. SLP-76–defic...

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Detalles Bibliográficos
Autores principales: Chiang, Y. Jeffrey, Sommers, Connie L., Jordan, Martha S., Gu, Hua, Samelson, Lawrence E., Koretzky, Gary A., Hodes, Richard J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213313/
https://www.ncbi.nlm.nih.gov/pubmed/15238603
http://dx.doi.org/10.1084/jem.20040262

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213313/
https://www.ncbi.nlm.nih.gov/pubmed/15238603
http://dx.doi.org/10.1084/jem.20040262

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