Examination of Msh6- and Msh3-deficient Mice in Class Switching Reveals Overlapping and Distinct Roles of MutS Homologues in Antibody Diversification

Somatic hypermutation and class switch recombination (CSR) contribute to the somatic diversification of antibodies. It has been shown that MutS homologue (Msh)6 (in conjunction with Msh2) but not Msh3 is involved in generating A/T base substitutions in somatic hypermutation. However, their roles in...

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Detalles Bibliográficos
Autores principales: Li, Ziqiang, Scherer, Stefan J., Ronai, Diana, Iglesias-Ussel, Maria D., Peled, Jonathan U., Bardwell, Philip D., Zhuang, Min, Lee, KyeRyoung, Martin, Alberto, Edelmann, Winfried, Scharff, Matthew D.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213317/
https://www.ncbi.nlm.nih.gov/pubmed/15238604
http://dx.doi.org/10.1084/jem.20040355

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213317/
https://www.ncbi.nlm.nih.gov/pubmed/15238604
http://dx.doi.org/10.1084/jem.20040355

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