Cargando…
Essential Role of Lung Plasmacytoid Dendritic Cells in Preventing Asthmatic Reactions to Harmless Inhaled Antigen
Tolerance is the usual outcome of inhalation of harmless antigen, yet T helper (Th) type 2 cell sensitization to inhaled allergens induced by dendritic cells (DCs) is common in atopic asthma. Here, we show that both myeloid (m) and plasmacytoid (p) DCs take up inhaled antigen in the lung and present...
Autores principales: | de Heer, Hendrik Jan, Hammad, Hamida, Soullié, Thomas, Hijdra, Daniëlle, Vos, Nanda, Willart, Monique A.M., Hoogsteden, Henk C., Lambrecht, Bart N. |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2004
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213319/ https://www.ncbi.nlm.nih.gov/pubmed/15238608 http://dx.doi.org/10.1084/jem.20040035 |
Ejemplares similares
-
Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells
por: Kool, Mirjam, et al.
Publicado: (2008) -
The lung vascular filter as a site of immune induction for T cell responses to large embolic antigen
por: Willart, Monique A.M., et al.
Publicado: (2009) -
Activation of the D prostanoid 1 receptor suppresses asthma by modulation of lung dendritic cell function and induction of regulatory T cells
por: Hammad, Hamida, et al.
Publicado: (2007) -
Inflammatory dendritic cells—not basophils—are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen
por: Hammad, Hamida, et al.
Publicado: (2010) -
In vivo depletion of lung CD11c(+) dendritic cells during allergen challenge abrogates the characteristic features of asthma
por: van Rijt, Leonie S., et al.
Publicado: (2005)