Immunostimulatory oligonucleotides block allergic airway inflammation by inhibiting Th2 cell activation and IgE-mediated cytokine induction

A single treatment with a CpG-containing immunostimulatory DNA sequence (ISS) given before allergen challenge can inhibit T helper type 2 cell (Th2)–mediated airway responses in animal models of allergic asthma; however, the mechanism of this inhibition remains largely undefined. Here, we demonstrat...

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Detalles Bibliográficos
Autores principales: Hessel, Edith M., Chu, Mabel, Lizcano, Jennifer O., Chang, Bonnie, Herman, Nancy, Kell, Sariah A., Wills-Karp, Marsha, Coffman, Robert L.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213327/
https://www.ncbi.nlm.nih.gov/pubmed/16314434
http://dx.doi.org/10.1084/jem.20050631

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213327/
https://www.ncbi.nlm.nih.gov/pubmed/16314434
http://dx.doi.org/10.1084/jem.20050631

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