Tyrosine phosphatase MEG2 modulates murine development and platelet and lymphocyte activation through secretory vesicle function

MEG2, a protein tyrosine phosphatase with a unique NH(2)-terminal lipid-binding domain, binds to and is modulated by the polyphosphoinositides PI((4,5))P(2) and PI((3,4,5))P(3). Recent data implicate MEG2 in vesicle fusion events in leukocytes. Through the genesis of Meg2-deficient mice, we demonstr...

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Detalles Bibliográficos
Autores principales: Wang, Yingchun, Vachon, Eric, Zhang, Jinyi, Cherepanov, Vera, Kruger, Joshua, Li, Jun, Saito, Kan, Shannon, Patrick, Bottini, Nunzio, Huynh, Huong, Ni, Heyu, Yang, Hong, McKerlie, Colin, Quaggin, Sue, Zhao, Zhizhuang Joe, Marsden, Philip A., Mustelin, Tomas, Siminovitch, Katherine A., Downey, Gregory P.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213338/
https://www.ncbi.nlm.nih.gov/pubmed/16330817
http://dx.doi.org/10.1084/jem.20051108

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213338/
https://www.ncbi.nlm.nih.gov/pubmed/16330817
http://dx.doi.org/10.1084/jem.20051108

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