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Cysteine Protease Inhibitors Cure an Experimental Trypanosoma cruzi Infection

Trypanosoma cruzi is the causative agent of Chagas' disease. The major protease, cruzain, is a target for the development of new chemotherapy. We report the first successful treatment of an animal model of Chagas' disease with inhibitors designed to inactivate cruzain. Treatment with fluor...

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Detalles Bibliográficos
Autores principales: Engel, Juan C., Doyle, Patricia S., Hsieh, Ivy, McKerrow, James H.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1998
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213346/
https://www.ncbi.nlm.nih.gov/pubmed/9705954