A Hypermutable Insert in an Immunoglobulin Transgene Contains Hotspots of Somatic Mutation and Sequences Predicting Highly Stable Structures in the RNA Transcript

Immunoglobulin (Ig) genes expressed in mature B lymphocytes can undergo somatic hypermutation upon cell interaction with antigen and T cells. The mutation mechanism had previously been shown to depend upon transcription initiation, suggesting that a mutator factor was loaded on an RNA polymerase ini...

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Detalles Bibliográficos
Autores principales: Storb, Ursula, Klotz, Emily L., Hackett, John, Kage, Karen, Bozek, Grazyna, Martin, Terence E.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1998
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213363/
https://www.ncbi.nlm.nih.gov/pubmed/9705951

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213363/
https://www.ncbi.nlm.nih.gov/pubmed/9705951

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