A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation

Like Bcl-2, Mcl-1 is an important survival factor for many cancers, its expression contributing to chemoresistance and disease relapse. However, unlike other prosurvival Bcl-2–like proteins, Mcl-1 stability is acutely regulated. For example, the Bcl-2 homology 3 (BH3)–only protein Noxa, which prefer...

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Detalles Bibliográficos
Autores principales: Lee, Erinna F., Czabotar, Peter E., van Delft, Mark F., Michalak, Ewa M., Boyle, Michelle J., Willis, Simon N., Puthalakath, Hamsa, Bouillet, Philippe, Colman, Peter M., Huang, David C.S., Fairlie, W. Douglas
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213596/
https://www.ncbi.nlm.nih.gov/pubmed/18209102
http://dx.doi.org/10.1083/jcb.200708096

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213596/
https://www.ncbi.nlm.nih.gov/pubmed/18209102
http://dx.doi.org/10.1083/jcb.200708096

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