Expression profiling in APP23 mouse brain: inhibition of Aβ amyloidosis and inflammation in response to LXR agonist treatment

BACKGROUND: Recent studies demonstrate that in addition to its modulatory effect on APP processing, in vivo application of Liver X Receptor agonist T0901317 (T0) to APP transgenic and non-transgenic mice decreases the level of Aβ(42. )Moreover, in young Tg2576 mice T0 completely reversed contextual...

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Detalles Bibliográficos
Autores principales: Lefterov, Iliya, Bookout, Angie, Wang, Zhu, Staufenbiel, Matthias, Mangelsdorf, David, Koldamova, Radosveta
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2214725/
https://www.ncbi.nlm.nih.gov/pubmed/17953774
http://dx.doi.org/10.1186/1750-1326-2-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2214725/
https://www.ncbi.nlm.nih.gov/pubmed/17953774
http://dx.doi.org/10.1186/1750-1326-2-20

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