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Pore Structure Influences Gating Properties of the T-type Ca(2+) Channel α(1G)
The selectivity filter of all known T-type Ca(2+) channels is built by an arrangement of two glutamate and two aspartate residues, each one located in the P-loops of domains I–IV of the α(1) subunit (EEDD locus). The mutations of the aspartate residues to glutamate induce changes in the conduction p...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2003
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2217349/ https://www.ncbi.nlm.nih.gov/pubmed/12743166 http://dx.doi.org/10.1085/jgp.200308794 |