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Mechanism of Rectification in Inward-rectifier K(+) Channels

Rectification in inward-rectifier K(+) channels is caused by the binding of intracellular cations to their inner pore. The extreme sharpness of this rectification reflects strong voltage dependence (apparent valence is ∼5) of channel block by long polyamines. To understand the mechanism by which pol...

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Detalles Bibliográficos
Autores principales: Guo, Donglin, Ramu, Yajamana, Klem, Angela M., Lu, Zhe
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2217370/
https://www.ncbi.nlm.nih.gov/pubmed/12642596
http://dx.doi.org/10.1085/jgp.200208771