Protons Block BK Channels by Competitive Inhibition with K(+) and Contribute to the Limits of Unitary Currents at High Voltages

Proton block of unitary currents through BK channels was investigated with single-channel recording. Increasing intracellular proton concentration decreased unitary current amplitudes with an apparent pKa of 5.1 without discrete blocking events, indicating fast proton block. Unitary currents recorde...

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Detalles Bibliográficos
Autores principales: Brelidze, Tinatin I., Magleby, Karl L.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2217450/
https://www.ncbi.nlm.nih.gov/pubmed/14981139
http://dx.doi.org/10.1085/jgp.200308951

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2217450/
https://www.ncbi.nlm.nih.gov/pubmed/14981139
http://dx.doi.org/10.1085/jgp.200308951

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