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Coupling of Voltage Sensing to Channel Opening Reflects Intrasubunit Interactions in Kv Channels

Voltage-gated K(+) channels play a central role in the modulation of excitability. In these channels, the voltage-dependent movement of the voltage sensor (primarily S4) is coupled to the (S6) gate that opens the permeation pathway. Because of the tetrameric structure, such coupling could occur with...

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Detalles Bibliográficos
Autores principales: Labro, Alain J., Raes, Adam L., Snyders, Dirk J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2217479/
https://www.ncbi.nlm.nih.gov/pubmed/15623896
http://dx.doi.org/10.1085/jgp.200409194